Toshihiko Hirano Selected Research

cepharanthine

1/2021	Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases.
12/2020	Potent antitumor activity of cepharanthine against triple-negative breast cancer spheroids compared with tetrandrine.
1/2020	Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study.
9/2019	Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mTOR signal modification in glucocorticoid resistant human leukemia Jurkat T cells.

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Toshihiko Hirano Research Topics

Disease

17	Leukemia 01/2021 - 05/2002
14	Neoplasms (Cancer) 01/2021 - 11/2003
13	Breast Neoplasms (Breast Cancer) 12/2020 - 01/2015
8	Myasthenia Gravis 09/2018 - 12/2003
8	Infections 06/2017 - 06/2006
5	Rheumatoid Arthritis 10/2021 - 03/2004
4	Atopic Dermatitis (Atopic Eczema) 01/2021 - 01/2006
4	Necrosis 01/2020 - 04/2009
4	Psoriasis (Pustulosis Palmaris et Plantaris) 05/2017 - 10/2007
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2021 - 09/2019
3	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2021 - 09/2019
3	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 02/2010
3	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 09/2014 - 01/2003
3	Cytomegalovirus Infections (Inclusion Disease) 06/2014 - 01/2012
3	Melanoma (Melanoma, Malignant) 01/2012 - 06/2009
3	Disease Progression 01/2012 - 01/2006
2	Triple Negative Breast Neoplasms 12/2020 - 01/2018
2	Death (Near-Death Experience) 03/2020 - 11/2018
2	Hypertension (High Blood Pressure) 07/2019 - 01/2017
2	Hematologic Neoplasms (Hematological Malignancy) 06/2018 - 12/2013
2	Acute Promyelocytic Leukemia 01/2018 - 07/2015
2	Pre-Eclampsia (Preeclampsia) 01/2017 - 04/2015
2	Substance Withdrawal Syndrome (Withdrawal Symptoms) 08/2014 - 01/2011
2	Septic Shock (Toxic Shock Syndrome) 10/2011 - 06/2006
2	Ulcer 07/2010 - 04/2009
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2009 - 04/2007
2	Fibrosis (Cirrhosis) 01/2009 - 01/2006
2	Nephrotic Syndrome (Syndrome, Nephrotic) 12/2008 - 06/2006
2	Bacterial Infections (Bacterial Infection) 10/2007 - 06/2006
2	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 01/2005 - 12/2003
2	Crohn Disease (Crohn's Disease) 05/2004 - 10/2002
2	Ulcerative Colitis 05/2004 - 07/2002

Drug/Important Bio-Agent (IBA)

22	GlucocorticoidsIBA 01/2021 - 07/2002
12	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2021 - 05/2002
12	Tacrolimus (Prograf)FDA LinkGeneric 12/2019 - 12/2003
11	tetrandrineIBA 01/2021 - 11/2003
10	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2019 - 12/2003
9	arsenic disulfide (realgar)IBA 01/2020 - 02/2014
8	Pharmaceutical PreparationsIBA 10/2021 - 05/2002
8	CytokinesIBA 01/2021 - 02/2010
8	Daunorubicin (Cerubidine)FDA LinkGeneric 08/2020 - 02/2003
7	MitogensIBA 10/2021 - 10/2008
7	Calcineurin InhibitorsIBA 09/2018 - 01/2006
7	Prednisolone (Predate)FDA LinkGeneric 10/2011 - 09/2002
6	Vitamin K 2 (Vitamin K2)IBA 10/2021 - 01/2018
6	Methylprednisolone FDA LinkGeneric 11/2020 - 09/2002
5	arseniteIBA 01/2020 - 07/2015
5	ArsenicIBA 01/2020 - 08/2017
5	SuperantigensIBA 01/2009 - 01/2006
4	cepharanthineIBA 01/2021 - 09/2019
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 05/2004
4	Aligeron (AS 2)IBA 12/2011 - 02/2003
4	Messenger RNA (mRNA)IBA 05/2004 - 09/2002
3	Methotrexate (Mexate)FDA LinkGeneric 10/2021 - 01/2013
3	Interleukin-10 (Interleukin 10)IBA 01/2021 - 04/2009
3	AlkaloidsIBA 01/2021 - 08/2017
3	VitaminsIBA 10/2020 - 01/2012
3	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 08/2020 - 09/2002
3	SteroidsIBA 12/2019 - 01/2005
3	Tyrosine (L-Tyrosine)FDA Link 07/2019 - 04/2015
3	Biomarkers (Surrogate Marker)IBA 06/2017 - 12/2013
3	Concanavalin AIBA 05/2017 - 06/2006
3	sofalcone (Solon)IBA 04/2015 - 04/2009
3	Arsenicals (Arsenic Compounds)IBA 11/2014 - 09/2011
3	Arsenic Trioxide (Trisenox)FDA Link 01/2013 - 02/2003
3	AntibodiesIBA 01/2012 - 02/2010
3	Cholinergic ReceptorsIBA 01/2012 - 02/2010
3	Staphylococcal enterotoxin FIBA 04/2007 - 01/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021 - 04/2009
2	Interleukin-2 (IL2)IBA 01/2021 - 08/2015
2	Interleukin-17 (Interleukin 17)IBA 01/2021 - 08/2015
2	Estrogen ReceptorsIBA 12/2020 - 01/2018
2	Vitamin K 1 (Phylloquinone)FDA LinkGeneric 10/2020 - 01/2018
2	Vitamin K 3 (Menadione)FDA Link 10/2020 - 11/2015
2	Immunosuppressive Agents (Immunosuppressants)IBA 08/2020 - 07/2002
2	dicarboxydine (DCD)IBA 03/2020 - 11/2018
2	Antineoplastic Agents (Antineoplastics)IBA 01/2020 - 01/2013
2	Adenosine Triphosphate (ATP)IBA 06/2017 - 06/2014
2	Cholecalciferol (Vitamin D3)FDA Link 05/2017 - 01/2012
2	EndoglinIBA 01/2017 - 04/2015
2	Hormones (Hormone)IBA 08/2015 - 01/2015
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 11/2014 - 01/2012
2	Hydrocortisone (Cortisol)FDA LinkGeneric 08/2014 - 01/2012
2	Dacarbazine (DIC)FDA LinkGeneric 01/2013 - 01/2012
2	arsenic acid (arsenate)IBA 12/2011 - 09/2011
2	RoxithromycinIBA 10/2011 - 01/2009
2	Anti-Bacterial Agents (Antibiotics)IBA 10/2011 - 01/2009
2	Chalcone (Benzalacetophenone)IBA 06/2009 - 04/2009
2	Therapeutic UsesIBA 01/2005 - 12/2003
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2021
1	sinomenineIBA 01/2021
1	BenzylisoquinolinesIBA 01/2021
1	Mitogen-Activated Protein KinasesIBA 01/2021
1	JNK Mitogen-Activated Protein KinasesIBA 01/2021
1	InterleukinsIBA 01/2021

Therapy/Procedure

11	Therapeutics 01/2018 - 01/2002
4	Kidney Transplantation 10/2016 - 04/2007
3	Drug Therapy (Chemotherapy) 09/2019 - 11/2003
3	Liver Transplantation 01/2009 - 01/2006
2	Renal Dialysis (Hemodialysis) 06/2017 - 04/2007